The mosaic Ad26/Ad26 plus gp140 HIV-1 vaccine induced comparable and robust immune responses in humans and rhesus monkeys, and it provided significant protection against repetitive heterologous SHIV challenges in rhesus monkeys. This vaccine concept is currently being evaluated in a phase 2b clinical efficacy study.
The new vaccine is protective in monkeys, and antibodies against HIV were generated in humans. it has to be tested and watched further whether the vaccine will protect against infection in real scenario.
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