One way to treat infertility is to cause ovulation using medicine. Clomiphene citrate is taken by mouth and has usually been tried first. Letrozole is another oral medicine that can be used and can be particularly helpful in patients with PCOS and is often tried first. If this is unsuccessful, injected fertility medicines called gonadotropins may be given to stimulate the growth of an egg. Women with PCOS must be watched very carefully when these medicines are used to make sure that they are not responding too much as this increases the risk of multiple births.
If a woman is overweight, losing weight can help improve ovulation patterns and fertility.
Insulin-sensitizing medicines such as metformin can help the body use insulin more effectively to improve ovulation in some patients with PCOS.
This may also lower the risk of developing diabetes or metabolic syndrome.
In vitro fertilization (IVF) may help women with PCOS get pregnant if other treatments do not work.