IVF treatment is an option for couples struggling with infertility. ICSI is an advanced fertility treatment for male infertility. This gives the best success in the hands of expert IVF doctors and embryologists. But at times poor quality eggs can't make good quality embryos. Even with good numbers of eggs an IVF cycle can't succeed. This is most likely if the egg quality is poor. Premature ovarian failure, a condition in which the woman attains menopause much earlier than usual. As a result, her ovary doesn't produce eggs. Premature menopause occurs typically before age 40. With good quality eggs and embryos repeated implantation failure may occur. At times this may be due to the genetic issues with the mother. Parents wanting to avoid transmission of a hereditary disorder to their children from mother may opt for donor eggs. Donor egg is the last option for women with poor ovarian reserve. This again may be due to defect from birth or destruction of ovaries due to cancer, endometriosis, previous surgery, infections, etc.